COMPARATIVE ANALYSIS OF THE INFLAMMATORY RESPOND OF THE VASCULAR WALL AFTER IMPLANTATION OF BIORESORBABLE SCAFFOLDS AND EVEROLIMUS COVERED STENTS IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE
Natal’ya Alekseevna MUSIKHINA, Tat’yana Ivanovna PETELINA, Ivan Sergeevich BESSONOV, Natal’ya Alimgiraevna GALEEVA, Elena Aleksandrovna GORBATENKO, Alina Igorevna KOSTOUSOVA
Tyumen Cardiology Research Center, Tomsk National Research Medical Center of RAS
Keywords: ишемическая болезнь сердца, ангиопластика, воспаление, биорезорбируемые скаффолды, coronary artery disease, angioplasty, inflammation, bioresorbable scaffolds
Abstract
Aim - to conduct a comparative analysis of markers of inflammatory reaction of the vascular wall in patients with stable coronary artery disease (CAD) after implantation of bioresorbable scaffolds (BS) and everolimus-eluting stents during short observation period. Material and methods. 20 patients with stable CAD and mono-vessel coronary bed lesion with indication to percutaneous coronary intervention (PCI) were studied. Group 1 consisted of 9 patients with implanted stent covered with everolimus; group 2 consisted of 11 patients with implanted BS. Biochemical inflammatory markers were defined at the admission time, in 1 day, 4 days and 1 month after PCI. Results. In 1 day after PCI both groups expectedly showed cytokine level growth, including interleukin 6 (IL-6), as a respond to the vascular wall lesion with the following decrease in 4 days to the initial level. On the second day after PCI serum content of matrix metalloproteinases 9 (MMPs-9) was increased in groups 1 and 2 of patients. Lowering of MMPs-9 with no reaching the initial level in 1 month was noticed only in group 2, whereas group 1 kept high concentration of MMPs-9. The comparable groups had the maximum content of soluble CD40-ligand (sCD40L) on the 4th day with a little lowering after 1 month only in group 2. High level of high-sensitive C-reactive protein (CRP) remained during the entire follow-up period in both groups. Conclusion: Patients with stable CAD after implantation of BS and everolimus covered stents did not have any differences in dynamics of mediators of acute inflammation phase. Persistent high levels of MMPs-9, sCD40L and also elevated concentration of CRP assume prolonged character of the vascular wall inflammatory respond, being more expressed after implantation of everolimus covered stents.
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