ON THE INTERACTION OF LIQUID FLOW IN THE SYSTEM В«BLOOD CAPILLARY - TISSUE - LYMPHATIC CAPILLARY»
Irina Vasil’yevna SHVAB1, Vadim Valer’yevich NIMAEV2,3
1Institute of Computational Technologies of SB RAS
2Research Institute for Clinical and Experimental Lymphology - Branch of the Institute of Cytology and Genetics of SB RAS
3Novosibirsk State University
Keywords: микроциркуляция, математическое моделирование, лимфатический дренаж, интерстиций, microcirculation, mathematical modeling, lymphatic drainage, interstitium
Abstract
The article deals with the interaction of fluid flow in the «blood capillary - tissue - lymphatic capillary» system. On the one hand, the mutual influence of the components involved in the system is an important basis for maintaining homeostasis from the point of view of physiologically occurring processes, and changes in their structural and functional properties can be a triggering factor for impaired fluid balance, the appearance and development of a number of pathological processes, syndromes and diseases. The paper presents a mathematical model of metabolic processes that occur at the microcirculatory level and include the following interrelated processes: blood flow in the capillaries, fluid movement in the interstitium, metabolism between interstitial fluid and tissue cells, drainage into lymphatic capillaries. An approach is used to take into account the mutual influence of blood flow in the blood capillary and interstitial fluid in the tissue. The analysis of the solution results is carried out, the effect of various microcirculation parameters on the intensity of metabolic processes is investigated, and the most significant parameters are identified.
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