STRUCTURAL TRANSFORMATIONS
IN AXILLARY AND MESENTERIC LYMPH NODES IN CHEMOTHERAPY and SURGICAL
TREATMENT OF EXPERIMENTAL mammary tumor
Oleg Vasilievich KAZAKOV, Alexey Vasilievich KABAKOV, Alexandr Fedorovich POVESHCHENKO, Tatyana Vladimirovna RAYTER, Dmitriy Nikolaevich STRUNKIN, Alexandr Petrovich LYKOV, Vladimir Iosifovich KONENKOV
Research Institute of
Clinical and Experimental Lymphology - Branch of Federal Research Center
Institute of Cytology and Genetics of SB RAS
Keywords: молочная железа, лимфатические узлы, опухоль, оперативное лечение, профилактическое лечение, mammary gland, lymph nodes, tumor, surgical treatment, preventive treatment
Abstract
Was conducted histological
study axillary and mesenteric lymph nodes in breast cancer induced by
intramammary administration of N-methyl-N-nitrosourea, chemotherapy
according to the CMF scheme (cyclophosphamide, methotrexate,
5-fluorouracil), operative removal of breast tumors (6.5 months from the
beginning of the experiment). The results of the study. At chemotherapy
of breast cancer, compared with the group with breast cancer without
treatment, there was a decrease in the number of tumor cells in the
axillary lymph nodes in comparison with mesenteric lymph nodes. The
decrease in the area of the paracortical zone and the area of secondary
lymphoid nodes remain in the axillary lymph nodes, in comparison with
breast cancer without treatment. The reduction of the paracortical zone
square remains in mesenteric lymph nodes. The area of lymphoid nodules
with germinative centers decreases. The number of postcapillary venules
with high endothelium and the number of macrophages in structural zones
grow down. In the axillary lymph nodes after surgical treatment of
breast cancer and chemotherapy in comparison with the treatment of
breast cancer only with cytostatics, there is decrease in the area of
the paracortical zone (with an increase in the number of small
lymphocytes) and medullare cords. The area of lymphoid nodules with
germinative and without germinative centers increases. In mesenteric
lymph nodes, drainage function is reduced, increased the area of the
paracortical zone, reduced the areas of lymphoid nodules with
germinative centers and medullare cords (increased proliferative
activity of cells), macrophage reaction in the cortical substance was
revealed. Conclusion. The severity of structural transformations in
cytoarchitectonics of the axillary and mesenteric lymph nodes depends on
the treatment method.
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