INTERACTION OF BIORESORBABLE COMPOSITE IMPLANTS MADE BY SOLUTION BLOW SPINNING WITH TISSUES
Denis Evgen’evich KULBAKIN1,2,3,4, Evgeniy Lkhamatsyrenovich CHOYNZONOV1,2,3,5, Nadezhda Viktorovna CHERDYNTSEVA6,4, Evgeniy Nikolaevich BOLBASOV5, Valeriy Anatol’evich SVETLICHNYI4, Ivan Nikolaevich LAPIN4, Sergei Ivanovich TVERDOKHLEBOV5, Aleksandr Aleksandrovich ZHERAVIN7, Lyudmila Nikolaevna BONDAR6, Vladimir Mikhaylovich PERELMUTER6
1Cancer Research
Institute of Tomsk National Research Medical Center of RAS
2Siberian
State Medical University
3Tomsk State University of Control Systems and
Radioelectronics
4Tomsk State University
5Tomsk Polytechnic University
6Cancer Research Institute of Tomsk National Research Medical Center of RAS
7Meshalkin National Medical Research Center of Minzdrav of Russia
Keywords: реконструктивная хирургия, регенеративная медицина, биодеградируемый имплантат, полимолочная кислота, остеогенез, reconstructive surgery, regenerative medicine, biodegradable implant, polylactic acid, osteogenesis
Abstract
This work represents the
results of the study of the surrounding tissues reaction to the
implantation of bioresorbable implants formed by the solution blow
spinning from polylactic acid and ultrafine calcium phosphate powders,
depending on the time and place of implantation. Using scanning electron
microscopy it is shown that implants formed from randomly interwoven
fibers have interconnected open porosity. It was established that the
addition of calcium phosphate ultrafine powders does not cause changes
in the formed implants structure. Histological investigation of tissue
specimens from the implantation site revealed a high ability of created
implants to successful integration with surrounding tissue after 15 days
from the moment of implantation. Complete or partial implant resorption
with substitution by own tissues was registered at 90 days after
implantation. It was established that implantation of composite
bioresorbable implants on the ilium bone stimulates the osteogenic
process better than the implantation on skull bone within the same
period. It was defined that scarification of the outer cortical plate in
implant contact points with bone tissue increases the implants ability
to stimulate osteogenic process. It was shown that the composite
implants filled with calcium phosphate dibasic dehydrate in ultrafine
powder form have the largest ability to stimulate osteogenesis.
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