EFFECT OF COMPLEX TREATMENT
USING PLATELET AUTOPLASMA ON CLINICAL AND LABORATORY PARAMETERS OF
PATIENTS WITH ENDOGENOUS UVEITIS AND MACULAR EDEMA
Nataliya Sergeevna ARBENEVA1, Tatyana Anatolyevna CHEKHOVA1, Vladimir Ivanovich BRATKO1, Olga Olegovna OBUKHOVA2, Olga Mikhaylovna GORBENKO2, Alya Petrovna SHVAYUK2, Olga Vladimirovna POVESHCHENKO3, Aleksandr Nikolaevich TRUNOV4,5, Valeriy Vyacheslavovich CHERNYKH1
1S. Fyodorov Eye Microsurgery Federal State Institution of Minzdrav of Russia, Novosibirsk Branch
2Research Institute for Experimental and Clinical Medicine of Federal Research Center or Fundamental and Translational Medicine
3Research Institute for
Clinical and Experimental Lymphology - Branch of Federal Research Center
Institute of Cytology and Genetics of SB RAS
4S. Fyodorov Eye
Microsurgery Federal State Institution of Minzdrav of Russia,
Novosibirsk Branch
5Research Institute for Experimental and Clinical
Medicine of Federal Research Center or Fundamental and Translational
Medicine
Keywords: эндогенный увеит, макулярный отек, цитокины, тромбоцитарная аутоплазма, endogenous uveitis, macular edema, cytokines, platelet autoplasma
Abstract
Purpose: to study the
clinical and laboratory efficacy of the platelet autoplasma use in the
complex treatment of endogenous uveitis associated with systemic
diseases accompanied by macular edema. Material and methods. The study
included 46 people (72 eyes) with endogenous uveitis and macular edema.
The diagnosis was made on the basis of the ophthalmological examination,
including visometry, tonometry, biomicroscopy, ophthalmoscopy,
perimetry, B-scan, optical coherence tomography of the macular zone,
photoregistration of the anterior, posterior segment of the eye. The
examination was carried out on the 1st and 10th day of treatment. The
main group consisted of 22 people (36 eyes) who underwent
anti-inflammatory therapy and the introduction of platelet plasma in the
region of the pterygopalatine fossa. The control group consisted of 24
people (36 eyes) receiving only anti-inflammatory therapy (diprospan 0.5
para-equatorially №1, dexazone 4 mg intravenously №5, intravenous lasix
2.0 ml №5, electrophoresis with prednisolone № 7). All patients
underwent the definition of IL-4, IL-6, IL-8, IL-17 in tear fluid before
the study and on the 10th day. Results. The significant increase in the
concentrations of pro-inflammatory cytokines (IL-17A and IL-8) and IL-4
and IL-6 involved in the development of autoimmune response and chronic
inflammation was found in the patients with endogenous uveitis and
macular edema. The use in the treatment of endogenous uveitis with
macular edema of platelet autoplasma leads to more pronounced
improvement of clinico-ophthalmological parameters (improvement in
visual acuity, retinal photosensitivity, and retinal thickness
reduction) relating to the comparison group. A decrease in the activity
of the inflammatory process was noted in the main group after treatment,
which is manifested by a significant decrease in the concentrations of
IL-17A, IL-8, IL-4, IL-6, relating to the data obtained in the
comparison group. The proposed scheme of complex treatment allows
reducing the frequency of relapses of the pathological process.
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