Platelet microvesicles and their role in providing hemostatic capacity (literature review)
Andrey P. Momot1, Natalia O. Tsarigorodtseva2, Dmitry V. Fedorov2, Konstantin M. Bishevski2, Natalia V. Vostrikova2, Elena E. Klimova2
1Altai Branch of National Research Center for Hematology of Minzdrav of Russia, Barnaul, Russia
xyzan@yandex.ru
2Altai State Medical University of Minzdrav of Russia, Barnaul, Russia
misssherlockian@gmail.com
Keywords: тромбоцитарные микровезикулы, система гемостаза, кровотечения, криопреципитат, platelet microvesicles, hemostatic system, bleeding, cryoprecipitate
Abstract
In recent years the role of microvesicles in endocrine system transmission, in providing cellular connectivity, in transportation of proteins and nucleic acids from one cell to another, in angiogenesis regulation, in inflammatory reactions and in dissemination of tumors is actively studied. This article reviews the mechanisms of microvesicle formation, the structure of microvesicles and their potential value as biomarkers. Among all essential reactions involving microvesicles one thing especially stands out: their direct participation in providing hemostatic reactions for bleeding control in case of a solution of continuity in blood vessels due to different reasons. Platelet microvesicles play an important role in this process, and it has been proved by several experimental and clinical studies. In this review we evaluate prospects for clinical use of one of modern blood components - cryoprecipitate - as the source of platelet microvesicles.
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